ET chatted with the 39-year-old actor at the Tribeca Film Festival on Monday, where he was premiering his new thriller, Devil's Gate, in which he plays Jackson Pritchard, the husband of an FBI agent -- clearly, a major departure from his beloved portrayal of Jack Pearson on This Is Us.
"I tell you what, they got the same initials. Jack Pearson has three kids, that's a lot to manage," he said, when asked what the biggest difference between the two characters is. "But Jackson Prichard has really got a heavy, heavy weight, a heavy burden on his soul."
We attempted to get Ventimiglia to give us an update on season two of This Is Us, but unfortunately, he couldn't say much. "I'm sorry, I got nothing," he explained. "I'm out in Tribeca, we're off season right now, we're not even filming. I have no beard, mustache or goatee, so just sit back patiently and wait. There's 18 great episodes [from season one]. If you want to re-watch them, go ahead. Otherwise, we'll be back by fall time."
That didn't stop him from gushing over his co-stars, however. The California native had nothing but amazing things to say about seeing Mandy Moore, Chrissy Metz and Susan Kelechi Watson featured in People's World's Most Beautiful issue.
"I knew that Mandy, Chrissy and Susan were in the issue, but I didn't know their involvement," he said. "So when I saw those stories, I literally on Susan's, I pulled over and I was listening to her with that letter to her younger self and I was in tears. And then I saw Chrissy had one and [I had the] same reaction."
"I get the front row seat to how beautiful those women are as human beings, so it's nice that fans and audiences see a little bit more through the magazine," he added.
But does Ventimiglia have any plans to start his own campaign for People's Sexiest Man Alive with his onscreen brothers, Sterling K. Brown and Justin Hartley?
"I tell you what, Sterling K Brown is -- he's sexy. He is sexy, dictionary-like classic," he joked. "Nah, Sterling K. Brown is the sexiest ever, but then there is Justin Hartley. I don't know!"