Octavia Spencer, who starred in 2011's The Help alongside Ellis, is one of many who posted her condolences to social media.
"Just got word that we lost @nelsanellisofficial," Spencer, 47, wrote on Instagram, alongside a photo of the actor and several hashtags including "#RIPNelsanEllis" and "brilliantactor." "My heart breaks for his kids and family."
"It will forever be a point of sadness for me that I never had the chance to work with Nelsan during my time on True Blood," Carolyn Hennesysaid in a statement to ET. "He was one of the finest talents I have personally seen on that or any show."
Actress Gabrielle Union shared that she was "blown away" by the tragic news.
"My God, such a beautiful soul and talented artist. Blown. Away. #RIP," Union wrote on Twitter.
Several of Ellis' True Blood co-stars also took the time to remember their friend and actor who portrayed the loveable Lafayette on the hit HBO series, including Anna Paquin, Sam Trammell, Michael McMillian, Todd Lowe, Joe Manganiello, Kristin Bauer and Lauren Bowles.