Neil Patrick Harris did not take kindly to James Woods' insensitive joke.
On Monday, the 70-year-old actor commented on a photo of two parents and their son at the Orange County Pride Parade in California. The father was holding a sign that read: "My son wears dresses and makeup ...get over it!"
WATCH: Neil Patrick Harris Splits His Pants During Epic Broadway Riff-Off With James Corden
The boy's mother also held a sign that read: "I love my gender creative son."
"This is sweet," Woods responded to the image. "Wait until this poor kid grows up, realizes what you've done, and stuffs both of you dismembered into a freezer in the garage."
MORE: James Woods Sues Twitter User for $10 Million Over 'Cocaine Addict' Tweet
Upon seeing the tweet, Harris slammed Woods, writing: "Utterly ignorant and classless, Mr. Woods. I'm friends with this family. You know not of what you speak, and should be ashamed of yourself."
GLAAD also responded to the Casino star's tweet, writing: "You're literally the reason organizations like us have to exist."
This wouldn't be the first time Woods' tweets have offended. In May, he made remarks about CNN's Anderson Cooper, writing: “As his butt plug dislodges during a newscast…”
Meanwhile, the mother in the photo, Lori Duron, couldn't be prouder of her son, and expressed this in a blog post titled, "My Gender Creative Son’s First Pride."
“My sweet, fabulous, rainbow boy has never received so many compliments,” Duron wrote. “He’s used to getting stares and whispers when we’re out in public. He’s not used to getting the smiles, hugs and encouragement he received at Pride.”
WATCH: George and Amal Clooney Join Twins Club! Jennifer Lopez, Chris Hemsworth and More Stars With Double the Joy
Harris is the father of 6-year-old twins, Harper and Gideon, with husband David Burtka, and on Father's Day, shared what being a parent means to him. "Being a parent is the single most challenging thing I've ever done [and] continue to do, but it's also far and away the greatest joy in my life," he wrote. "It has given me purpose, taught me patience, and expanded my heart. Thanks, @dbelicious, for taking the journey of two lifetimes with me. #grateful"
WATCH: Neil Patrick Harris Celebrates 13-Year Anniversary With Husband David Burtka -- 'The Love Has Never Waned'