Margot Robbie Hosting 'Saturday Night Live' Season 42 Premiere, The Weeknd Set as Musical Guest

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Harley Quinn is coming to Saturday Night Live!

The sketch comedy series is kicking off its 42nd season with Suicide Squad star Margot Robbie guest-hosting the premiere on Oct. 1.

The Weeknd is returning to Studio 8H for his second time as the show's featured musical guest. The 26-year-old "Can't Feel My Face" singer will be promoting his upcoming album, Starboy, which is due out Nov. 26.

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SNL underwent a surprising cast shake-up during the hiatus with the departure of longtime cast members Taren Killam and Jay Pharoah as well as newcomer Jon Rudnitsky, who had only been with the show for one season.

Meanwhile, the show promoted staff writer Mickey Day to the role of featured player, and signed on improv comic Alex Moffat and stand-up comic Melissa Villasenor, who was a semi-finalist during season six of America's Got Talent in 2011.

WATCH: 'SNL' Adds Three New Cast Members for Season 42 -- Meet the Fresh Faces!

Robbie recently appeared as the murderous Harley Quinn in Warner Bros. and DC Comics' Suicide Squad, where the 26-year-old Australian actress was the standout star in the otherwise critically panned superhero flick. It was recently announced that Robbie will be starring in her own Harley Quinn solo film.

On Wednesday, Robbie was one of several stars to read "Mean Tweets" on Jimmy Kimmel Live! Check out the video below to see the latest installment in the hilarious segment.