While Blunt is starring in one of the most anticipated films of the year, The Girl on the Train, Hanks is reprising his role as Robert Langdon in Inferno, the third installment of Dan Brown's Da Vinci Code franchise.
Hanks is also coming off the release of biopic, Sully, which shattered box office expectations by reeling in $35 million its opening weekend.
The movie stars' accompanying musical guests are also sure to bring eyeballs to the show, as Mars released his first solo song in four years on Thursday. The 30-year-old singer dropped the super catchy "24K Magic" with a Las Vegas-inspired music video, showing off the GRAMMY winner's impressive dance moves.
Likewise, Gaga released a new single, "Million Reasons," earlier this week in promotion of her fifth full-length album, Joanne, which is just weeks away from release.
SNL's 42nd season is off to a strong start as last week's premiere, hosted by Margot Robbie and featuring musical guest The Weeknd, pulled in 11.8 million viewers in live-plus-three-day ratings. The NBC sketch comedy show is expected to keep the momentum going this Saturday with host Lin-Manuel Miranda and musical guest Twenty One Pilots.