EXCLUSIVE: 'Supergirl' Cast Dishes on Crossovers, Karamel and the New Big Bad!

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ETonline's Leanne Aguilera sat down with the cast of Supergirl at San Diego Comic-Con on Saturday for news on villains, crossovers, and the return of Karamel!

Supergirl herself, Melissa Benoist, noted the more serious tone of the season three teaser that debuted during the show's Comic-Con panel. "She's got these scales going on all the time, trying to balance everything as a woman, as a superhero, and love and career," she said of her conflicted character.

"Now all the rocks of the scale are on Supergirl."

EXCLUSIVE: 'Supergirl' Season 3 First Look Features New Villains, Sanvers Kiss and the End of Kara Danvers?!

Also weighing on Kara is the difficult decision she had to make at the end of last season, sending away Chris Wood's Mon-El. According to Benoist, "She lost her entire world, she probably has some abandonment issues. She had to literally make him abandon her. So I think she's dealing with that."

But all is not lost for Karamel, as Supergirl's love interest is set to return in the new season. So, how do they get back together?

"The first step is Mon-El coming back," joked Wood. If only it weren't for that wayward pod, a common problem in the Supergirl universe.

"Every pod is knocked off course except Kal-El's!" Benoist exclaimed.

EXCLUSIVE: 'Supergirl' Melissa Benoist and Chris Wood Dish on Karamel's 'Sweet' Relationship!

What do know for sure? According to Jeremy Jordan, who plays Winn Schott, "The first episode takes place six months after the events of the finale." So we're facing a little bit of a time jump between the finale and the new season.

The cast also confirmed that Odette Annable'sseason three villain, Reign, is going to cause some serious problems for our heroes.

"I'm coming in to cause some trouble," said Annable. "I'm the greatest villain that's ever reigned. There's never been a villain on the show that's ever been seen in this way."

RELATED: 'Supergirl' Casts Odette Annable As Main Villain for Season 3

Fans can also look forward to another four-part crossover event -- with fellow CW super-shows Arrow, The Flash and DC's Legends of Tomorrow -- with Supergirl playing a larger role this time around. The rest of the cast is ready to join in too, as Wood fake-teased, "Mon-El kills the Green Arrow," to everyone's shock. "It's a big crossover!" he added defensively as the group cracked up.

Annable is ready for a fight, though. "I'd like to take all of them on," she said of the event.

For more on Supergirl season three, watch the video below!

EXCLUSIVE: 'Supergirl' Star Melissa Benoist Teases Her Characters Struggles in Season 3