McCarthy shined in a sunny, yellow, flower-pattered dress that was the perfect complement to Falcone's Aegean blue suit, complete with a yellow pocket square to match his wife's gorgeous gown.
"This is a fantastic collaboration between myself and Daniela Kurrle, who I worked with for years," McCarthy told ET's Kevin Frazier of her dress on the red carpet outside the TLC Chinese Theatre in Hollywood.
The 45-year-old comedian explained how she and Kurrle designed the dress, taking into account all the "vintage things I love" and all the different styles she's wanted to wear in the past. "And then a baby [was] born. A dress baby," McCarthy joked.
Falcone couldn't help but marvel at his wife's stunning style, exclaiming, "Isn't she gorgeous? She looks great!"
The actor and filmmaker also had nothing but praise for his wife's role in the long-awaited reboot, and addressed the backlash against the film, which was largely aimed at the decision to remake the 1984 classic with an all-female cast.
"I just think that's dumb," Falcone said. "[Director] Paul Feig is a friend and he's a really, really smart person and he chose the funniest people he could think of and they happen to be women. So, you know, I have no problem with it."
McCarthy and Falcone, who have made two films together with Falcone at the helm and McCarthy in the lead, acted together in Feig's acclaimed 2011 comedy, Bridesmaids. (He’s the air marshal that McCarthy’s Megan sets her romantic sights on.) Feig later directed McCarthy in 2013's The Heat and the hilarious espionage send-up Spy in 2015.
As for the comedy queen, she says she's excited to be part of the blockbuster reboot, and revealed that she's already been blindsided by the cultural impact the big budget comedy has had in her own life.
"My kids were playing with our action figures today and I just thought, 'I don't know what to make of this,'" McCarthy shared. "I kept trying to, like, peek around the corner and listen to what they were saying. I couldn't quite get anything, except they kept calling us out by name instead of character name. They're like, 'Leslie, get in here!' I'm like, 'She plays Patty, but I know what you mean.' It's confusing."
McCarthy co-stars alongside Leslie Jones, Kate McKinnon and Kristen Wiig as the new team of paranormal investigators in this iteration of the beloved film.
Ghostbusters hits theaters on July 15.
McCarthy wasn't the only star rocking a killer dress to the premiere. Jones, who had publically opened up about having trouble finding a designer to make a gown for her, teamed up with Project Runway winner Christian Siriano to create a fiery, off-the-shoulder gown that stunned. Check out the video below for a look at the SNL star’s "dream" dress.