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After six years of dating, Gillian Anderson and Mark Griffiths are calling it quits.

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A rep for the 43-year-old X-Files star confirmed the news to US Weekly, stating that she and her partner have separated "amicably." The couple shares two children: Oscar, 5, and Felix, 3.

Before dating Griffiths, Anderson was previously married to director Clyde Kotz. The actress later wed filmmaker Julian Ozanne, divorcing just two years later.