Blake Shelton and Miranda Lambert split in July after four years of marriage, and inevitably the former country couple was going to be the target of some lighthearted ribbing.
On Wednesday night in Nashville, Brad Paisley and Carrie Underwood teased Shelton about the breakup, with a little help from The Muppets.
Addressing the elephant in the room, Underwood said they couldn't "ignore the breakup that really rocked our world."
"The one that's on everybody's mind. Two people in this very room that we all know and love," Underwood said, solemnly. "Splitsville."
Cutting to the audience, the camera turned to Kermit and Miss Piggy -- they also announced their split earlier this year -- who were sitting apart from each other.
Paisley quickly jumped in, adding, "On a completely unrelated topic, howdy Blake!"
To his credit, Shelton seemed to find the zinger pretty funny, waving and smiling to the cameras after Paisley's comment.
But Shelton wasn't the only celeb Underwood and Paisley called out at the CMA Awards -- they also mocked Josh Duggar's cheating scandal with a song about Ashley Madison and joked about Caitlyn Jenner's transition, singing, "Bruce Jenner's a babe now."
The joke about Shelton and Lambert's divorce was made even more awkward by the "God Gave Me You" singer's new relationship with his fellow coach on The Voice, Gwen Stefani, who also split from her husband Gavin Rossdale earlier this year.
Shelton's rep confirmed to ET that The Voice coach was dating Stefani on Wednesday. Check out the video below for more on the new couple.