"I'd have to obviously stay open to [the idea]," said Tisdale, whose HSM co-star, Zac Efron, starred in the acclaimed big-screen Hairspray remake in 2007.
However, the 30-year-old actress said that the pressure would be a lot greater than what she's accustomed to.
"With sitcoms it's in front of a live audience, but you're able to go back and, like, redo it if you mess up," Tisdale explained, adding that she "couldn't imagine" how embarrassing it would be if she "messed up" on live TV.
While there's no word yet on whether fans will hear Tisdale singing the hits from Hairspray, she did reveal that she's working on some new music of her own -- but it might be a while before it's ready.
"I have some ideas, but I’m just in the studio kind of feeling out where my voice is," Tisdale shared. "Right now I'm just trying to figure out what kind of music I want to do and where I fit in."
In the meantime, Tisdale is keeping herself busy with her newest endeavor: a line of graphic tees
"A lot of the stuff is inspired by me and my girlfriends and what we say together," said Tisdale, who also serves as creative director for Signorelli.
With all her various projects occupying her time, Tisdale says that starting a family with her husband, Christopher French,
isn't something she's planning on in the immediate future.
"I'm not having kids anytime soon!" Tisdale told ET, laughing.
While having children might not be in the cards for her just yet, she is working on creating a new show for herself to star in.
"I think one of the main priorities right now is producing a TV show for myself and doing a character that I love," said Tisdale, who executive produces Freeform sitcom Young & Hungry.