The premiere begins with Grace and Will once again showing how in-tune they are while playing “Heads Up!” Meanwhile, Jack is trying to get a new Grindr profile pic and Karen is zoned out with her signature martini in hand.
"I had the craziest dream. You were there and you were there," Karen says after she gets snapped awake by Jack and looks at Will and Grace. She then turns to Jack and says, "You weren’t."
"In my dream, Will was living with a swarthy man in uniform and Grace was married to a Jew doctor," Karen continues, with Will replying, "Yeah, we were," referring to his apparently now-ex, Vince D'Angelo (Bobby Cannavale) and Grace's ex-husband, Leo Markus (Harry Connick, Jr.). "But we’re single now."
"That tracks," Karens jokingly says. "What happened to the children you had who grew up and got married to each other?"
"That never happened," Will replies.
"Ugh, what a relief. Nobody wants to see you two raise kids," she quips, looking to Jack, who echoes her sentiments. "Yeah, I mean, what would be funny about that?" he snaps back.