Schumer shared videos and photos from the vaccination site, dancing in the car with her husband, Chris Fischer, and declaring, "This is my going to get the vaccine energy," fist pumping in the car.
At the site, the Inside Amy Schumer star rocked a sparkly mini-dress with a cutout hole in the arm to honor the occasion.
"I just wanted to maybe entertain some of the workers here and during your 15 minutes, but I'm sorry if you were going to use this time to meditate," Schumer joked to the room full of people waiting to get their jab.
She went on to thank those in the medical field for all their work during these incredibly tough, and now "hopeful" times.
"I want to thank all the brave people in the medical field. But more than them I want to give a shout out to me," she joked in her Instagram caption. "I’m awesome I love the people of New York. Even the annoying ones. It’s nice to see all of them. I feel excited and hopeful. I hope you do too."