Prior to handing out awards, Cuoco began the show with a taped segment that featured a LL Cool J, Katniss Everdeen (aka Jennifer Lawrence) and characters from Twilight, who gave the actress kick-butt lessons.
After the night was officially underway, Katy Perry took home Favorite Pop Artist, Favorite Music Video, Favorite Music Fan Following and Favorite Female Artist, while Robert Downey Jr. won Favorite Movie Actor and Favorite Superhero.
Here's a list of some other notable winners:
Favorite Comedic TV Actress - Lea Michele
Favorite Comedic TV Actor - Chris Colfer
Favorite Dramatic TV Actress - Ellen Pompeo
Favorite Dramatic TV Actor - Nathan Fillion
Favorite Movie Actress - Jennifer Lawrence
Favorite Movie - The Hunger Games
Favorite Late Night Talk Show Host - Jimmy Fallon
Favorite Country Artist - Taylor Swift
Favorite Song - What Makes you Beautiful by One Direction