Most of Wilson's jokes were made at her own expense, making light of her figure.
"I was a bit surprised they asked me to host, and so was MTV -- they thought I was Adele," the Pitch Perfect star joked at the top of the show.
The night's biggest winners were the stars of Marvel's The Avengers and Silver Linings Playbook. The Avengers took home Best Villain, Best Fight and the night's most prestigious award -- Movie of the Year. Silver Linings stars Bradley Cooper and Jennifer Lawrence won Best Male and Best Female Performance as well as Best Kiss.
Special awards included MTV Trailblazer (given to Emma Watson), Comedic Genius (claimed by Will Ferrell) and the Generation award (handed to Jamie Foxx).
Perhaps the biggest winners of the night were Hunger Games fans, who were rewarded with a new two-and-a-half-minute teaser trailer embedded below.
Here's a list of the night's most notable winners:
Movie of the Year: Marvel's The Avengers Best Hero: Bilbo Baggins Best Male Performance: Bradley Cooper (Silver Linings Playbook) Best Female Performance: Jennifer Lawrence (Silver Linings Playbook) Breakthrough Performance: Rebel Wilson (Pitch Perfect) Best Shirtless Performance: Taylor Lautner (The Twilight Saga: Breaking Dawn - Part 2) Best Fight: Marvel's The Avengers Best Kiss: Jennifer Lawrence and Bradley Cooper (Silver Linings Playbook) Best WTF Moment: Jamie Foxx and Samuel L. Jackson (Django Unchained) Best Villain: Tom Hiddleston (The Avengers)