"I don't think so," the GRAMMY winner told ET. "This is going to be her evening to shine. I think that she would probably not want to share the stage too much, although I would personally think that would be great!"
They might not unite on stage but if they meet offstage, it will be for the very first time.
"We have not seen each other to this day," Richie said.
Adele has won 10 GRAMMYs, but isn't up for any awards this year because her third studio album, 25, didn't meet the eligibility deadline.
Richie, a four-time GRAMMY winner, will receive another distinction on Saturday, when he is presented with his MusiCares honor. The GRAMMY charity provides money to artists who have fallen into hardship or addiction. Past honorees include Sir Paul McCartney, Barbra Streisand and Bob Dylan.
The adoration for Richie doesn't stop there! An all-star tribute to the singer-songwriter is planned for the GRAMMYs, which will feature John Legend, Demi Lovato, Luke Bryan and Meghan Trainor.