"It's not gonna happen. That is just not gonna happen, because that would not be my strength," she insisted. "My strength is bringing people together and my strength is connecting people to ideas. My strength is allowing people to see the best of themselves even in the worst of times and circumstances."
Further denying that she would hit the campaign trail, Winfrey added, "That is not my thing. That would not be what I would be able to do well."
This is not the first time that the Queen of Talk has vowed never to run for the highest office in the land. During an interview with CBS This Morning in October, she declared, "There will be no running of office of any kind for me."
She is also quoted as telling The Hollywood Reporter's Awards Chatter podcast, "I will never run for public office."
However, in March, Winfrey admitted during an interview with Bloomberg Mediathat getting into politics never even crossed her mind until Donald Trump was elected president.
"I thought, ‘Oh, gee, I don’t have the experience, I don’t know enough,'" she said. "And now I’m thinking, ‘Oh.'”
However, Winfrey's longtime partner, Stedman Graham, told The Los Angeles Times that he could actually see her running for president. “It's up to the people,” he said after her Golden Globes speech. “She would absolutely do it."
Golden Globe winner Saoirse Ronan also told ET that Winfrey would have her vote for president. Check out our exclusive interview with the Lady Bird star: