Wintour then does her best impression of Schumer's stand-up, touting, "Men and women are sooo different."
That's when the two decide to change lives, and while Schumer looks gorgeous in Wintour's role, she's not too good at being the fashion mogul. Meanwhile, Wintour nails her comedy routine. "Wintour is coming," she tells the laughing audience at New York City's Comedy Cellar before dropping the mic.
During her interview with Vogue's Jonathan Van Meter, Schumer admits that she doesn't consider herself a fashionista. "I don’t think it’s stupid; there’s no moral reasoning. It’s just not my thing," she says of the fashion industry. "I think that there’s a misconception in fashion that everybody wants in. I'm happy to remain out."
The outspoken comedian also talked about losing her virginity as a teenager. "I was always boy crazy, but I wasn’t promiscuous,” she says. "[My friends] were acting out sexually years before me. I loved being around that, but I didn’t have sex until I was 17. And I didn’t give a blow job until I was well into college.”
Schumer jokingly adds, "I’m sure I had some sort of d**k in my mouth, but I wasn’t performing sex acts until later."
While Schumer was quite candid in her Vogue interview, she revealed to ET that she plans to share quite a bit with her fans in her upcoming memoir, The Girl With the Lower Back Tattoo. "People are going to know everything about me," she said, adding that the book will explore her "childhood, how she got her big break in comedy, her family and feminism."