Another snap shows her jumping high into the air, flaunting her Alexander McQueen top, pants and sneakers.
In her accompanying interview, Zendaya gets candid on how far she's come since her first starring role as Rocky Blue in Shake It Up on the Disney Channel, and why she doesn't say "yes" to everything that comes her way.
"A lot of people don't realize their power," she explains. "I have so many friends who say yes to everything or feel like they can't stand up for themselves in a situation … no, you have the power."
There's a lot of firsts for Zendaya this summer. In addition to her landing the Vogue cover, she will also be making her feature film debut in Marvel's Spider-Man: Homecoming, out July 7.