Patrick Dempsey made a name for himself in the '80s with teen comedies like Can't Buy Me Love and Loverboy. However in the '90s, Dempsey's was mostly off the radar until he won a high-profile role in 2002's Sweet Home Alabama. In 2005, he shot to stardom when he became the lead in Grey's Anatomy. Since then Dr. McDreamy has been the crush of women all over the world. Recently, Dempsey starred in Transformers: Dark of the Moon.