Playing himself, Hale appears in the finale as the newest member of D’s Café’s waitstaff alongside Billy (Billy Eichner), Lola (Shakina Nayfack) and Matthew (Cole Escola).
Liu plays Veronica, a morally corrupt, taste-challenged, highly successful alpha female. Veronica is the book editor who gives Marilyn (Andrea Martin) a chance to publish her own book.
Cho has a multi-episode arc as advertising executive Todd, testing the limits of romance for Billy (Billy Eichner), who has yet to have a long-term relationship on the show. Season three will follow the pair as Billy learns to navigate “couple” things.
The former West Wing star appears as Aunt Bonnie, Marilyn's (Andrea Martin) “trashy” sister who never met a man or drug she didn’t try. "We offered her the role because we knew she would be amazing," Klausner told ET about landing the actress. "It was important that we have somebody who was fabulous and she was kind enough to totally knock it out of the park."
The Night Of star appears on the series as Marilyn’s (Andrea Martin) former lover, Dusty, from her free-spirited youth as a nude model. (Yes, you read that correctly!) “I’m about to [film] a beautiful, romantic scene with John,” Martin told ET earlier this year.
Playing himself, Wilmore is the host of a late-night series (on a set that looks strangely similar to Samantha Bee’s Full Frontal) that briefly employs Billy (Billy Eichner) as a warmup emcee.
O’Donnell plays Vanessa, a member of Alcoholics Anonymous whom Julie (Julie Klausner) turns to for support.
The longtime daytime TV talk show host brings his expertise to Difficult People, offering advice to Denise (Gabourey Sidibe) and Nate (Derrick Baskin) on how to deal with Matthew’s (Cole Escola) tantrums.
On the series, the Schitt’s Creek star plays a man hired by Julie (creator Julie Klausner) on a TaskRabbit-like app.
Jackie Hoffman and Fred Armisen
The pair reprise their roles as Rachel and Garry Epstein, respectively.