The 78-year-old music legend was also honored as the MusiCares Person of the Year during GRAMMYs weekend.
The iconic singer-songer took the stage during the GRAMMYs premiere ceremony on Sunday -- with the help of a cane -- to accept the award for Best Historical Album for her collection, Archives, Vol. 1: The Early Years (1963–1967).
The award marks Mitchell's 10th career GRAMMY. She was honored with a lifetime achievement award in 2002, and was also celebrated at the Kennedy Center Honors back in December 2021.
Mitchell and Bonnie Raitt also teamed up during the GRAMMYs ceremony to introduce a performance by their friend and collaborator, Brandi Carlile.
Ahead of GRAMMYs night, Mitchell was recognized as the 2022 MusiCares Person of the Year on Friday. MusiCares is the foundation of the GRAMMYs' governing body, the Recording Academy, and provides health and human service aid to the music community.
"That was such an incredible evening for me," the 78-year-old performer marveled as she took the stage to accept her honor, later joking, "To hear my music performed so well by everyone that was onstage, I can retire now and just let other people do it."
The legendary artist later joined the musicians for a group performance of her hits, "The Circle Game" and "Big Yellow Taxi."
ET spoke to Mitchell and she reflected on receiving the prestigious honor.
"It's good, I hope I'm a good influence on music," she told ET's Nischelle Turner. "My music's pretty eccentric in a way. It's a very eclectic, you know, [which is] what I grew up on and what I listened to."
She also commented on possibly collaborating with Harry Styles, who is a big fan of hers and named his upcoming third album, Harry's House. "Harry's House" is also the name of her song off her 1975 album, The Hissing of Summer Lawns.
"We have these jams at my house from time to time, you know, and a lot of people come from Ireland and England ... and they're a lot of fun, maybe he'll show up at one of them," she said.