Meza only held the title since May, after the 2020 Miss Universe was postponed significantly due to the coronavirus pandemic and subsequent shutdowns.
Sandhu beat out 79 other contestants from qualifying nations across the globe to earn the title and the crown. She is only the third Indian woman to be crowned Miss Universe.
Meanwhile, Miss Paraguay, Nadia Ferreira, was the night's runner-up, with Miss South Africa, Lalela Mswane, coming in as the second runner-up.
The 70th annual Miss Universe was held at Universe Dome at Port of Eilat in Israel and was hosted yet again by Steve Harvey. This marked Harvey's sixth time as host in seven years, after he skipped the 2020 Miss Universe due to COVID-19 safety concerns.
Indian actress Priyanka Chopra Jonas, who won Miss World in 2000, congratulated Sandhu for "bringing the crown home after 21 years."
For more on the Miss Universe pageant, check out the video below.