Dempsey (a.k.a. Dr. Derek "McDreamy" Shepherd) said goodbye to Grey's Anatomy earlier this year when he was dramatically killed off after an 11-season run. In the episode, Derek was rushed to the hospital after getting hit by a semi-truck. Although he was alive and breathing when he arrived, the improperly-trained doctors at the hospital ultimately cost him his life, and Derek's wife, Dr. Meredith Grey (Ellen Pompeo), was left with the difficult choice to take her husband off life support.
ABC issued a statement following the episode, explaining that Dempsey was leaving the show "to pursue other interests."