Cruise and Holmes, who have a 16-year age difference, have one daughter together, Suri, 6.
The couple married in an Italian castle in 2006, after a whirlwind romance that made headlines from the start. Perhaps the most infamous incident? Cruise's 2005 appearance on The Oprah Winfrey Show, in which he ecstatically professed his love for Holmes while jumping on a couch.
"She is an extraordinary person, and if you spent five minutes with her, you'd see it. Everything she does, she does with this beautiful creativity. She's funny and charming, and when she walks into the room, I just feel better. I'm a romantic. I like doing things like creating romantic dinners, and she enjoys that," he said.