Boston.com reports that around 20 people were aboard the bus at 9:30 a.m. when the crash occurred. At least 11 people were reportedly taken to the hospital.
"People were screaming and they were everywhere on the bus," one passenger said of the accident that reportedly came without warning.
The news source reports that none of the patients sustained life-threatening injuries.
A representative from 20th Century Fox tells ET, "A Boston city bus hit a truck associated with an as yet untitled motion picture comedy starring Sandra Bullock and Melissa McCarthy. The incident, unrelated to the film's production, occurred at about 9:34 a.m., near Roxbury District Court. Fourteen passengers on the bus and one crew member who was on the truck sought medical attention. Principal photography of the Paul Feig (Bridesmaids) directed movie began last week and is expected to wrap in September."
The storyline of the film reportedly follows an FBI agent and a Boston police officer who form an alliance to capture a mob boss.