"If you ask everybody in this country to raise their hands if they've ever sold drugs or ever tried any illegal substance, more than 50 percent of us would be in jail right now," Grenier said during an appearance on Real Time with Bill Maher.
Grenier and fellow producer Bert Marcus were able to call on celebrities that have been affected by drugs either directly or by losing friends to addiction.
Eminem opened up about the overdose that almost killed him, warning others, "You don't get another chance."
In the film, the rapper is candid about his past addiction to pain killers, which caused his organs to start shutting down.
Susan Sarandon, Woody Harrelson and Curtis "50 Cent" Jackson also provided interviews for the documentary available now On Demand and iTunes.