The 59-year-old actor, who's starred in dozens of films since the '70s, said that his passion for the topic led him to deliver an impromptu speech at the event urging his fellow Hollywood comrades to take action on the matter.
"I don't want to lose any more artists. It's too much already," he said during his speech.
With a variety of options available to treat substance abuse, Travolta, who has been a member of Church of Scientology since 1975, discussed Scientology's program for detoxifying a drug abuser.
Joining Travolta at the event, which was hosted in Hollywood, was wife Kelly Preston, who gave an update on her son Benjamin, who will turn three years old in November.
"Ben's amazing. He's getting so big, talking up a storm, and [is] just so funny," the 50-year-old actress said. "He loves to play. We play 'monsters' all the time and hide and I'm the bad monster. ... He's just really great."
Watch the video above to see Travolta's spontaneous speech on substance abuse.