"When he comes, he also brings his friends," said the hotel's general manager Giampaolo Ottazzi. "He's a very good friend of ours. He's been coming here for 15 years, because here he finds the right privacy."
One of the most special places in the hotel is said to be the bar, which features drinks that George helped create.
One of their cocktails, called the Buona Notte or Good Night, makes use of Casamigos tequila -- a brand made by George and friend Rande Gerber. They also have a drink called Nina's Passion, which is named after George's mom.
The wedding will reportedly take place at the Ca' Farsetti palace in Venice on Saturday. George is expected to have a small ceremony of only 60 guests.
While the official guest list remains a mystery, rumors abound that Rande Gerber's wife Cindy Crawford will be there, as well as Julia Roberts, and Brad Pitt and Angelina Jolie, with Brad rumored to be a possible best man.
George, 53, and Amal, 36, became engaged in April after first meeting in September 2013.