But in a new interview with Today's Matt Lauer, the 33-year-old star says that her label as "the sex comic" and being "hilariously dirty" due to some of her racier jokes, is actually a bit unfair.
"Honestly when people say I'm dirty and I talk about sex a lot, I don't feel like I talk about it any more than is normal, and I think because I am a woman that people notice it more," she points out to Lauer. "You know, I'll get up and in a 15-minute set, have one joke about sex sometimes, but they're still like, 'Oh, the sex comic.' But then a guy will come up and like, literally take his [bleep] out onstage, and it'll be like, 'He's a thinker; let's give him a show.'"
"I don’t feel dirty, I'm just talking about my truth," she adds.
Though Judd Apatow, who produced her highly anticipated big screen comedy Trainwreck, begs to disagree.
"She's dirty -- I brought my daughter to the Comedy Cellar to see Amy, and I had forgotten the content of Amy's act and let's just say, my daughter learned things," he jokes.
Apatow also reveals on Today how he first noticed Amy, and brought her into his well-known circle of friends and collaborators including Steve Carell, Seth Rogen and Lena Dunham. While stuck in Los Angeles traffic, Apatow caught Schumer on Howard Stern's radio show, and obviously, liked what he heard.
"[I] thought, 'Amy is really warm and funny and brutally honest' ... and I thought, 'Oh I'd like to see her in a movie,'" he recalls.
"I'm the first woman to leave Howard Stern without regretting it," Amy jokes.
Trainwreck, which Schumer wrote the screenplay for and marks her first starring big screen role, hits theaters on July 17. Co-starring Bill Hader and NBA star LeBron James, the film revolves around a commitment-phobic writer [Schumer] who falls for a sports doctor [Hader]. Watch the hilarious trailer below: