And her famous family couldn't be more supportive of her debut as woman.
"We were given this life because you were strong enough to live it! I couldn't be prouder!!! Caitlyn, You are beautiful!!!" Khloe Kardashian tweeted, who Jenner has previously said had the hardest time dealing with her transition.
"Caitlyn Jenner for Vanity Fair ? Annie Leibovitz! How beautiful! Be happy, be proud, live life YOUR way!" Kim Kardashian echoed.
"Now that's a cover," his 19-year-old daughter Kendall Jenner wrote about the big news. "Be free now pretty bird."
"My angel on earth! #caitlyn," her 17-year-old daughter Kylie Jenner also Instagrammed.
36-year-old Kourtney Kardashian also expressed her awe over Caitlyn's cover. "Freedom! Stunning," she wrote on Instagram.
Plenty of celebs also commented on the Vanity Fair cover on Monday to show their overwhelming support, including Ellen DeGeneres, Katy Perry, Maria Shriver and more. Read on below: