"I’m f–ked worse than Donald Trump / On Lexapro in Mexico across from a Texaco in a McDonald’s drunk," the rapper freestyled, referencing the GOP candidate’s stance on immigration.
Never a stranger to controversy, the rapper also threw down a line about Caitlyn Jenner that some are claiming is transphobic.
"I invented prick, and that’s a true statement / I see the b-tch in you, Caitlyn / Keep the pistol tucked like Bruce Jenner’s d–k," he rapped, before pausing to add, "No disrespect though, not at all / No pun intended, that took a lot of balls."
Eminem, whose real name is Marshall Mathers, even called out fellow musicians like Miley Cyrus and rapper French Montana in the nearly eight-minute freestyle.
“I’m coming through like a wrecking ball,” he rhymed. "You would swear I think highly of Miley / And I respect her the way I back-’Hannah’ / Excuse my French, Montana / But I am worried about nuttin'."
And Eminem made his encore count, slamming Bill Cosby and referencing the multitude of sexual assault claims against the comedian.
"I made monopoly off misogyny," he added at the end of the rap. "No wonder you scoff at me, it’s obvious I’m as off-putting as Bill Cosby is / Treat women like property, possessive like a noun with an apostrophe."
It's controversial stuff, but almost tame when you take a look back at the rapper's past lyrics. Watch Daniel Radcliffe tackle "The Real Slim Shady" in the video below.