After refusing to answer an inquiry about the most well-endowed actor she's ever worked with, host Andy Cohen decided to dig even deeper. He pried about Applegate's date with Brad Pitt at the 1989 MTV Video Music Awards where, as the story goes, she ditched him for another guy.
What Cohen wanted to know: "Who was the guy that you ditched Brad Pitt for?"
While Applegate wasn't so keen on dishing about ditching the 51-year-old actor, she did share with ET a pretty big Hollywood regret she's been carrying around.
Applegate was offered the role of Elle Woods in Legally Blondebut "got scared" and turned it down. The part ultimately went to Reese Witherspoon. "What a stupid move that was, right?" she quipped to ET.