"One of us was dressed as a dictator. I don't want to point fingers, but…," he said, pointing to Devito.
"I got that part because of the hat," Devito explained. "It fit me, it didn't fit him."
This isn't Clooney's first time working with the coffee company, however. The 54-year-old actor has represented the Swiss brand internationally since 2006. Watch the videos below to see him deliver the brand's catch phrase -- "Nespresso. What else?" -- from commercials released in July 2006 and January 2012.
Devito and Clooney are longtime friends, and have never been shy about their bond, especially when it comes to drinking.
"We end up on the front of the [New York] Post every time we hang out so we have to be really careful," Clooney told ET back in March. Their drink of choice? Limoncello's!
Watch the video below to hear more on their epic friendship.