Donning a black off-the-shoulder Dolce & Gabbana gown, the 39-year-old actress looked flawless on the red carpet at Los Angeles' Hyatt Regency Century Plaza Hotel. Witherspoon's 16-year-old daughter, Ava, posed alongside her mother in a flowy emerald green frock, while her 12-year-old son, Deacon, kept it cool and classic in a black tuxedo.
At the star-studded event, Reese -- who was also joined by her husband, Jim Toth -- was honored for her nearly 25-year career as an actress and producer. Former co-stars, directors, producers and friends -- including Kate Hudson, Jennifer Aniston and Jennifer Garner -- took the stage to speak about Reese's numerous accomplishments, praising her for her work both in front of and behind the camera.
Last year's recipient, Matthew McConaughey, did the honors of presenting his Mud co-star with the award. "The roles you were the most passionate about are the ones that resonate the most today," he noted, referring to Legally Blonde, Election, Wild and Walk the Line on stage.
"This whole experience is just overwhelming and unbelievable, because I'm literally just a girl from Nashville who had a big dream," Reese said during her acceptance speech.
Big dreams, indeed! Reese is the first female to win the award since Julia Roberts in 2007, preceded by Nicole Kidman in 2003, Jodie Foster in 1999, and Bette Midler in 1987.
Reese's mini-me, Ava, took to Instagram to share a sweet pic of her and her mom from inside the event, simply captioning it, "Congrats! #specialnight."