In the ad, Panettiere struts around an old shed and lights up a copper still, eventually pouring herself a big mason jar full of homemade white lightning. She then adds the special ingredient to a glaze sauce before taking a big bite out of the burger. See the commercial below!
The 26-year-old actress is now part of a long roster of A-listers who have appeared in the Carl's Jr. ads, as Kim Kardashian, Kate Upton, Audrina Patridge, Paris Hilton, Emily Ratajkowski and Heidi Klum have all starred in the sultry spots.
The Heroes alum -- who gave birth to her and fiancé Wladimir Klitschko's daughter, Kaya, in December 2014 -- has largely stayed out of the public eye since receiving treatment for postpartum depression.
Her first major appearance since treatment was in January at the 2016 Critics' Choice Awards, where ET spoke to the New York native about her recovery. "I've gotten an incredible amount of support and I was actually really surprised cause I feel like I grew up in this industry that, in my mind, was very judgmental," she explained.
Panettiere also made a guest spot in February on Lip Sync Battle, where she channeled Christina Aguilera for one epic performance. Find out who joined her on stage in the video below.