The Hail Caesar! actor also talks about his long and enviable career with the magazine, and says while he has no plans to retire soon, he is going to change the types of roles he accepts.
Specifically, don't expect Clooney to still be a leading-man 10 years from now.
"The reality is ... the kind of parts that I was doing, I'm not going to be doing anymore," he says. "Paul Newman did it best. He was a movie star, he was a leading man, and then he was like, 'Now I'm a character actor.' They just weren't as often and they weren't as much."
"I'm much more interested in doing films where the role makes sense for me," he continues. "I'm not gonna be carrying movies the way I did before. There are actors you'll see that try to hold on to this leading-man status long past the due date."
Clooney feels for those who handle fame these days, and doesn't know if he could do it given his past. Clooney says he’s grateful that be became famous in his 30s thanks to his beloved role in ER, as opposed to in his younger years.
"Used to be you could be as famous as you wanted. You show up at premieres and everybody cheers and you sign autographs, and then you go off and you drive out to a restaurant and go to dinner and you'd be left alone," he shares. "Every once in a while some paparazzi would sneak around, but now everybody's got a phone. If all this stuff existed when I was 25, it'd be me getting carried out of some bar by my feet. Cuz I did it all. I had all the fun that you should have. And it would have been multiplied by 10 times had I been famous and rich. I'm just lucky that the advent of camera phones happened when I was 43 years old or something."
The A-lister certainly seems content with growing older.
"I enjoy the work that I've been lucky enough to do and I wanna keep doing it," Clooney reflects. "I want to remain creative and be able to stay creative as long as they'll let me. So I wanna do that. But as I've gotten older and as I've gotten more secure in my life, there are a lot of other things that I care about more, which is: the people who don't have the luck that I have. There's a lot of people out there who could use some luck. There's a lot of people in this country, but there's an awful lot of people in this world that could use some luck. And sometimes luck is just shedding the spotlight on the fact that their lives are hell."