Rocking black Adidas jogging pants and black athletic vest with a white tee over a long-sleeved grey shirt, the former Grey's Anatomy star walked hand-in-hand with his wife, who kept her look casual in a striped shirt and black yoga pants.
An eyewitness tells ET that the actor and his wife appeared to be very affectionate throughout the day and were all smiles as they walked close together.
Patrick, 50, hosted the fundraiser for the non-profit charity walk, which is dedicated to raising money and awareness for sarcoma, a cancer of the connective tissues such as nerves, muscles and bones that is currently untreatable. The actor wore his wedding ring while speaking at the event.
During the event, Jillian snapped a selfie with Patrick and one of the events' other participants, which she shared to Instagram. "Helping to raise funds for a cure," she captioned the smiling snapshot.