"I f**king love you on that show, but are you glad you did it?" McCarthy bluntly asked Reid.
"I think the whole thing is absolutely so stupid and silly. And, like, we're not even talking about it because there's confusing things about it," answered Reid, who was hoping to promote her role as April Wexler in Sharknado 4: The 4th Awakens. "It's not worth the time to talk about."
That didn't stop McCarthy from pressing her to open up about the project, however. "Are you pissed off at the people's comments or just the show in general?" she asked.
"Babe, I asked you, please let's not talk about this show," begged Reid, clearly annoyed. "We're all here about Sharknado."
As if that weren't enough awkwardness for one radio show, McCarthy changed the subject by asking her guest to comment on her past experiences with plastic surgery. "People talked about your surgeries before," McCarthy, 43, said. "Are you still going through surgeries or are you past them?"
"No, I haven't had any surgery for a while, Jenny," Reid explained. "I think I've made that clear [that I'm done with plastic surgery] about 100 times. Maybe you only read the bad things, but I've made that really clear for so many years. But read what you want to read."
That last question apparently angered Reid so much, that she quickly decided to end her interview short. "It was really nice talking to you, and really, good luck with your show," she said, in which McCarthy replied, "Good luck to you too, and I'm so excited about Sharknado, and I hope you stay married, and I hope your knees get a little wobblier than they already are."
Ouch! Reid had one last insult for the host before walking out on her: "I hope your tits get even nicer, because they're amazing. The same guy who did mine, right? I'll always use your advice. You're the best. Bye."
McCarthy had to have the last laugh, however. "Love you, Tara," she exclaimed. "Good luck with Sharknado 18." Hear all of their digs in the interview below.
The shade didn't stop there. Following the awkward interview, McCarthy took to Twitter, writing, "Tune in for replay of @TheJennyMShow to hear why the only show we might ever be on together in the future will be Botched. Ch 109 8 pm EST."
Tune in for replay of @TheJennyMShow to hear why the only show we might ever be on together in the future will be Botched. Ch 109 8 pm EST
Reid's rep later released the following statement to ET:
"Tara is a positive person who is against women tearing each other down. She was bullied on Jenny's [show] and felt ambushed. She came into the show with a positive spirit and was in a happy mood. It was very unfortunate how Jenny shifted the conversation for her personal gain when the whole focus should be on Sharknado 4."
Back in February, McCarthy had much better luck when Kate Hudson was a guest on her Dirty Sexy Funny talk show. The Rock the Kasbah actress opened up about what it was like being "abandoned" by her biological father, Bill, as a child.