Cotillard and Pitt's upcoming World War II film is set in 1942, with Pitt playing an intelligence officer in North Africa who develops a romantic relationship with a female French Resistance fighter (Cotillard). The drama, helmed by Forrest Gump director Robert Zemeckis, hits theaters on Nov. 23.
In March, Cotillard and Pitt were snapped filming together in London, looking glamorous in period clothing.
The New York Post reported on Tuesday that Jolie filed for divorce from Pitt after she hired a private eye and learned Pitt was having an affair with Cotillard.
Jolie filed for divorce from Pitt on Monday, listing their date of separation as Sept. 15. But a source tells ET that the split has actually been "a long time coming," with the A-list pair fighting for the past year.
"Angelina runs a tight ship, and for years, Brad followed her orders," another source tells ET. "She always called the shots and he went along with it. In recent months, he hasn't been and has been living his life how he wants to live it."