During the Golden Globes, the 36-year-old actress revealed to ET how her nephew inspired her work with the organization, which provides cleft lip and palate surgeries to children in developing countries.
ET collaborated with Moet & Chandon for Toast for a Cause, where celebs toasted the charity of their choice and Moet generously donated $1,000 to organizations picked by the stars. And for Metz, this meant toasting Operation Smile.
"My nephew was actually born with cleft palate in his lip," Metz explained to ET's Carly Steel. "My sister was a young mom and she just didn't know --she wasn't educated about it."
"I mean obviously we have the facilities here but in other countries we don't and it's just something that we kind of take for granted," she continued, noting, "It's just a really beautiful cause."
The Golden Globe nominee is more than a fan of Operation Smile, she has been an ambassador for the medical service organization since 2016. "Operation Smile welcomes Chrissy Metz to our extended family of Smile Ambassadors," the non-profit said in a statement to ET. "Since meeting her at our Los Angeles Gala last year, Chrissy has been such a great advocate for Operation Smile and we are so pleased that she took a moment in the midst of the Golden Globe celebrations to toast Operation Smile as her favorite charity. Operation Smile salutes Chrissy and the shinning success of her stand-out role on NBC's This Is Us."
Founded in 1982, by plastic surgeon Dr. William Magee Jr. and his wife, nurse, Kathleen Magee, Operation Smile has performed more than 200,000 surgeries worldwide for children and young adults born with facial malformations.