“I bet you're laughing up there a bit more than you did before!” Stamos captioned the pic. “Happy Birthday my sweet mom. I miss you both madly.”
Loretta passed away in September 2014, with Stamos announcing he had “lost the love of my life,” on Instagram.
On Thursday, Stamos, 53, also paid tribute to Rickles.
“The world just got a lot less funny and just when we needed it the most,” Stamos wrote in the first of seven tweets honoring the star. “I will treasure our friendship forever sweet Don. #RIPDonRickles.”