Miley Cyrus to Perform on 'Chelsea Lately' Finale

Tuesday, August 26, marks the farewell episode of Chelsea Lately! Host Chelsea Handler will have a celebrity-filled sendoff before she heads over to Netflix to make history with a new talk show.

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ET has learned that Miley Cyrus will perform a live cover of Roy Orbison's "It's Over," with a special Miley touch, of course. Other stars joining in for the episode are Chelsea's ex-boyfriend 50 Cent, Justin Theroux, Melissa McCarthy, Gerard Butler and Kristin Chenoweth.

Chelsea has said that she chose not to renew her contract because he wants to focus more on human interest stories instead of pop culture. The 39-year-old has made a career out of doing things her own way and has never been afraid of ruffling feathers.

Throughout her success, Chelsea has remained humble and is still surprised by it. She told ET, "Even when I got my show the first time, I thought, ‘This is weird that they're giving me a show,’ so I just acted like I belong there and it seems to be working out great.”

Handler admitted to being skeptical of her success, at first. "I drove on this lot and it said Universal Studios and they're like, 'Ms. Handler, your parking spot is here,'” she recalled. “I'm like, 'What the hell is going on? This is a big practical joke. It's surreal’”

You may be surprised to know that the standup comic considers herself to be shy. "I know that people think I'm scary, but I'm not really,” she said. “I don't think that's for all women, I think some women. There's a lot of powerful women out there that are shy."

Speaking of powerful women, Chelsea is besties with a bunch of Hollywood A-listers. She's partied with Sandra Bullock and Jennifer Aniston, and even mixed business with pleasure with friend and This Means War co-star Reese Witherspoon.

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Only time will tell if Chelsea's celebrity gal pals will appear on her Netflix show. The series is still untitled and won't premiere until 2016. Check out this video to see more about this funny lady!