But Amy wasn't the only one getting raunchy at the awards show. Some of the nights' guests and presenters got a little dirty on their own. Here's a break-down of the six most inappropriate moments at the awards show!
1. Amy Schumer Comes to the Movies Prepared: In one of the dirtiest sketches ever aired during an awards show, Amy and a number of other women discuss and compare what… items they've brought to accompany them into a screening of Fifty Shades of Grey or Magic Mike XXL. "I brought my Sonicare and my showerhead."
2. Amy Schumer's Drought Humor: Introducing the cast of Magic Mike XXL -- including Channing Tatum, Joe Manganiello, Matt Bomer and Adam Rodriguez -- Amy joked about the California drought saying, "These four presenters are doing their part by making it rain in my Spanx. Lookin' at these guys, I'm the latest celebrity leak."
3. Dave Franco and Zac Efron Get Physical: When Dave and Zac won for Best Duo for their roles in Neighbors, the young stars got on stage decked out in their costumes from the film. The sketch they planned out ended up devolving into trying to hurt each other by just grabbing each other's junk. It was pretty awkward.
4. Amy Schumer as a Superhero Is Super Sexual: Before Amy introduced the cast of Fantastic Four, she donned a black superhero outfit (clearly attached to some cables) and told the crowd, "I have two superpowers. One, I have no gag reflex, and two, I can fly," before she was lifted into the air.
She later added, "Obviously I can't fly, but guess how I convinced the crew to let me fly for no reason! Because the first superpower is real."
5. Mark Wahlberg's Innuendos Get Lost in Translation: When Mark presented with Jessie J, he took the opportunity to see if the British singer could explain some English slang, asking "Take it in the gary and the dirtbox. What does that mean?"
"I don't know if that's for this moment in time to discuss that," an awkward Jessie J responded, looking as if it was a legitimately unplanned question.
"Is that a bad thing?" Mark asked. Turns out, it really is inappropriate.
6. Rebel Wilson Reveals a Bit Too Much About Her "Girl Power": Rebel came out dressed in angel wings and made a joke about the time she accidentally showed her "girl power" to President Barack Obama.
"By 'girl power,' I do mean vagina," Rebel added, before describing her "girl power" using Mexican food metaphors. Wow.