The show takes its meta theme to a whole other level when Lowe's real-life son John, 19, shows up. Lowe told ET's Ashlan Cousteau he did everything he could to dissuade his two boys from following in his footsteps.
"Here I thought I avoided all the pitfalls of raising actors," Lowe told ET's Ashlan Cousteau. "[John] is at Stanford and we're like, 'We did it! We got him into a big school!' He was one of the leading interns in stem cell research. Now he's going to be wearing makeup for a living."
Lowe's elder son, Matthew, will also have a part in the show, though acting may not be his ultimate career path. The 21-year-old college student is currently preparing for law school.
Lowe's onscreen brother, Fred Savage, gushed about his work on the show so far.