FIRST LOOK: Katie Holmes and Matthew Perry Dive Further Into the Kennedys' Tragedies in 'After Camelot'

Holmes makes another striking transformation into Jaqueline Kennedy for The Kennedys sequel, and this time she's joined by Matthew Perry.

Katie Holmes makes another striking transformation into Jaqueline Kennedy for The Kennedys sequel, The Kennedys: After Camelot, and this time she's joined by Matthew Perry.

The new miniseries picks up where the last one left off after the assassination of Robert Kennedy in the late '60s. Perry plays Senator Ted Kennedy with the help of a prosthetic nose, who is fighting the Chappaquiddick scandal in the series. The highly publicized incident took place on July 18, 1969 when a vehicle that Ted was driving veered into a body of water. Campaign worker Mary Jo Kopechne, 28, reportedly drown in the accident, while Ted swam to safety.

PICS: Katie Holmes Glows as Jackie Kennedy in Her Wedding Dress in 'The Kennedys: After Camelot'

This is just one of the many family sagas that get examined in the series, after the original stirred up controversy for its unflinching look at the lives of one of America's most prominent political families.

The four-hour series also delves into Jackie Kennedy's second marriage to billionaire, Aristotle Onassis and the tragic love story between John F. Kennedy Jr. and Carolyn Bessette.

Holmes last played Jackie O. in 2011, and ET was with her at The Kennedys premiere.

"As exciting as it was, it was daunting because she was loved by so many," Holmes explained to ET at the time. "So you walk into a situation trying your best, but everybody has their idea of who she was and so you're never going to please everyone."

WATCH: Katie Holmes Giddily Channels Jackie O. On Set of 'The Kennedys: After Camelot'

Despite the five-year hiatus, Holmes comfortably slips back into the role, baring a striking resemblance to the former first lady in photos from the set that were released in June.

In the pics, Holmes is in full character for a wedding scene, reenacting Jackie O.'s 1968 nuptials with Onassis.

WATCH: Katie Holmes and Suri Cruise Play Dress Up

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Clad in a recreation of Kennedy's iconic long-sleeve lacy white Valentino wedding dress, Holmes stunned next to actor Alexander Siddig, who plays the late Greek shipping mogul.

Kennedy married Onassis five years after her first husband, the late John F. Kennedy, was assassinated. The two were married for six years before he died in March 1975 of respiratory failure at the age of 69.

The Kennedys: After Camelot debuts in 2017 on Reelz.

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