Seacest made his big debut during Monday morning's show, almost a year after former co-host Michael Strahan left the program last May for a position at Good Morning America. A menagerie of guest co-hosts have since filled in, with Anderson Cooper, Andy Cohen, Rob Lowe, Fred Savage and Jerry O'Connell considered early front-runners for the full-time gig.
Ripa's pals, Cohen and Cooper, quickly took to Twitter to congratulate Seacrest on the job.
"Mazel @RyanSeacrest!! #LiveKellyRyan," Cohen wrote, while Cooper said he "can't wait to watch" Seacrest hang out with "the best person I know, @KellyRipa every day!"
Pennsylvania high school teacher Richard Curtis, who co-hosted the show a couple times after winning a contest, also gave a shout-out to Seacrest, while teasing that he's "available to fill in" during his school's summer break.