The 'DWTS' judge also took time off in March due to health issues.
Carrie Ann Inaba is prioritizing her health. On Tuesday, Inaba thanked everyone for their support after sharing on Instagram that she's taking a leave of absence from The Talk to focus on her well-being.
"I want to thank you all so much for the supportive messages I've received. I was profoundly touched by your love and understanding," Inaba began on her Instagram Story, adding that it "was not an easy decision" for her to make and that she "was scared."
"But your messages reminded me that everything will be alright," she continued. "Love you all so much and I thank you from the bottom of my heart."
On Monday, Inaba posted a video with a message to her fans, and also thanked her Talk family for their love and support. The 53-year-old dancer is a co-host on the CBS talk show alongside Sheryl Underwood, Elaine Welteroth and Amanda Kloots.
"Hi, everyone. So I wanted to let you know personally, that I have decided to take a leave of absence from The Talk to focus on my well-being," Inaba said. "I know you guys understand, health is the most important thing, so, I appreciate your support. I appreciate the love and support from The Talk family, and I hope to be back soon. Take care."
Inaba, who tagged the post #autoimmunewarrior and #toughchoices, quickly received supportive comments from Patti Stanger, Peta Murgatroyd, Kelly Ripa, Chrishell Stause and more.
ET has learned that Underwood, Welteroth and Kloots will be joined by guest co-hosts while Inaba takes a leave of absence from the show. Jerry O'Connell was the first of these guest co-hosts and he wasted no time sharing his "Da Butt" dancing skills a la Glenn Close.
In March, Inaba previously took time off from The Talk and in an Instagram Story video, she shared that she was experiencing pain.
"Not sure exactly what's been happening, but my arms started to go numb, and I was having sharp shooting pains as well, as well as the normal pain that I have every day which is pretty much getting unbearable," she said while lying in bed. "So, I've taken a few days off The Talk."
Inaba returned to The Talk on April 12, which was the show's first episode back after Sharon Osbourne stepped down as co-host following a heated on-air discussion about racism and an internal CBS review.
In February, Inaba wrote about her struggle with chronic illness on her website. "I've been diagnosed with several autoimmune conditions: lupus, Sjogrën’s, rheumatoid arthritis, fibromyalgia, and, most recently, vasculitis. For many years now, my life has been full of ups and downs, and lots of hard work to help me to feel my best, to land at a new normal that’s comfortable and sustainable."