The outspoken actress has signed on to star in an as-of-yet untitled multi-cam Fox sitcom created by the comedic minds behind It's Always Sunny in Philadelphia, Rob McElhenney and Rob Rosell, according to The Hollywood Reporter.
In the Middle America family sitcom, Remini stars as Jean, a politically conservative woman who simultaneously lives a very progressive life as a lesbian who is married to a woman named Betty.
Together, they raise Jean's two sons, alongside their father, Richie, who lives in Jean and Betty's garage.
McElhenney and Rosell's fellow Always Sunny producers Nick Frenkel, Charlie Day and Glenn Howerton will be serving as executive producers on the new sitcom, however, they are not expected to appear in the cast.
After appearing as a guest star during the first season of the show, Remini came on board as a series regular in the second season, after star Erinn Hayes -- who played the wife to James' character -- was unexpectedly killed off during the break between seasons.