The actress also opened up about shooting 'A Wrinkle in Time' right after the 2016 election. The Disney film hits theaters March 9.
The actress, who stars as Mrs. Whatsit, attended the L.A premiere of the Disney film with her eldest kids in tow.
The 41-year-old actress' son Deacon also attended the premiere, and Witherspoon told ET that her older kids were very excited to see the Disney film -- but her youngest, Tennessee, was home sleeping!
Check out some of the best-dressed stars from Monday's blue carpet premiere at the El Capitan Theater in Hollywood.
We totally see the resemblance!
ET sat down with Witherspoon, Winfrey and their 'Wrinkle in Time' co-star, Mindy Kaling, to chat about their upcoming movie, which hits theaters on March 9.
The Oscar winner spruced up her little piece of Hollywood on Sunday.
Here's a special behind-the-scenes look at what makes this movie so magical. 'A Wrinkle in Time' hits theaters on March 9.
The actress-writer transformed in "Mindy Mouse."
All eyes were on Oprah during Thursday's edition of 'The Ellen DeGeneres Show.'
Celebrities took to social media on Wednesday to call for gun control legislation after 17 people were killed in a tragic mass shooting at a high school in Parkland, Florida.
The 41-year-old actress is definitely dressed for the occasion!
From Nicole and Keith, to Chris and Elsa, ET has the stories behind some of Hollywood's best meet-cute moments, just in time for Valentine's Day.
The actress covers the March issue of 'Marie Claire' magazine.
