The 48-year-old Oscar winner will also be the guest speaker at the glitzy event at Universal Studios Hollywood, California, where celebrities and philanthropists will also enjoy a poker tournament and live auction.
"It was something that came to me a few days after my father passed away in '92 and I was working on my first film, Dazed and Confused," McConaughey told ET in November. "It was something that came to me in trying to cope with him no longer being there, then I started applying "just keep living" to anything I could in life and I couldn't find anywhere that it didn't fit."
The organization works with high school students, aiming to help them lead active lives and make healthy choices for their future.
“The work that Matthew McConaughey has done through his own foundation, his tireless commitment to giving back to the community, and his successful film and TV career, make him an obvious choice to be this year’s Inspiration Honoree,” City Summit founder Ryan Long told ET in a statement.
The gala will benefit non-profits including the Bright Future Foundation, Feed a Billion and Project NOW. It will conclude a three-day event, kicking off with City Summit, which aims to unite leaders to help support humanitarian efforts and will feature a keynote address by actor Ashton Kutcher.